Articles

Low-cost frequency-domain photon migration instrument for tissue spectroscopy, oximetry, and imaging

[+] Author Affiliations
Yunsong Yang

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104

Hanli Liu

University of Texas at Arlington, Biomedical Engineering, PO Box 19138, Arlington, Texas 76019

Xingde Li

University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania 19104

Britton Chance

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104

Opt. Eng. 36(5), 1562-1569 (May 01, 1997). doi:10.1117/1.601354
History: Received March 18, 1996; Revised Oct. 1, 1996; Revised Dec. 13, 1996; Accepted Dec. 13, 1996
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Abstract

We described a low-cost, frequency-domain photon migration spectroscopy instrument by using in-phase and quadrature demodulation technique in a 140-MHz homodyne system. A time constant of 1 ms was obtained. A frequency-division multiplexing technique was used for multiposition or multiwavelength applications, such as for tissue oximetry. By conducting several experiments on tissue/blood models, we show that the optical properties of tissue can be determined with this system by either using multiple source-detector separations at accuracy better than 8% or using single source-detector separation. The accuracy with the latter method can be improved to be 10% or better by choosing a proper calibration sample. A frequency-sweep system (30 to 700 MHz) was also implemented; the phase and amplitude measured on a tissuelike solution at 780 nm agreed to their theoretical values within 5% and 10% accuracy, respectively. © 1997 Society of Photo-Optical Instrumentation Engineers.

© 1997 Society of Photo-Optical Instrumentation Engineers

Citation

Yunsong Yang ; Hanli Liu ; Xingde Li and Britton Chance
"Low-cost frequency-domain photon migration instrument for tissue spectroscopy, oximetry, and imaging", Opt. Eng. 36(5), 1562-1569 (May 01, 1997). ; http://dx.doi.org/10.1117/1.601354


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