An innovative wavelength division multiplex-radio over fiber-passive optical network architecture for multiple access points (AP) based on multitone generation and triple sextupling frequency is proposed and demonstrated. A dual-drive Mach–Zehnder modulator (DD-MZM) is utilized to realize the multitone generation. Even sidebands are suppressed to make the adjacent frequency separation twice the frequency of the local oscillator by adjusting the modulation voltage of the DD-MZM. Due to adopting three fiber Bragg gratings to reflect the unmodulated sidebands for uplink communications source free at optical network unit (ONU), is achieved. The system can support at least three APs at one ONU simultaneously with a 30 km single-mode fiber (SMF) transmission and data rate both for uplink and downlink communications. The theoretical analysis and simulation results show the architecture has an excellent performance and will be a promising candidate in future hybrid access networks.