Imaging Components, Systems, and Processing

Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography

[+] Author Affiliations
Tetsuya Uchida, Yuya Inuzuka, Masaya Hasegawa

University of Toyama, Graduate School of Science and Engineering for Education, 3190 Gofuku, Toyama 930-8555, Japan

Shigeki Hirobayashi, Tadanobu Misawa

University of Toyama, Department of Intellectual Information Systems Engineering, Faculty of Technology, 3190 Gofuku, Toyama 930-8555, Japan

Opt. Eng. 54(3), 033108 (Mar 25, 2015). doi:10.1117/1.OE.54.3.033108
History: Received August 7, 2014; Accepted March 6, 2015
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Abstract.  In spectral-domain optical coherence tomography (SD-OCT), the limited resolution of the spectrometer causes nonuniformity of the interference signal. The latter, in turn, causes the sensitivity of SD-OCT to decrease, thereby limiting the imaging range and decreasing the axial resolution. We addressed this problem by applying nonuniform, nonharmonic analysis (NUNHA) with software that features high-frequency resolution without interpolation. We demonstrate the application of NUNHA in SD-OCT and compare it with conventional frequency analysis methods by simulating nonuniform interference signals. The results suggest that application of NUNHA in SD-OCT can provide acquisition of a clearer tomographic image, accurate analysis of fine and complex structures, and preservation of resolution and sensitivity at regions deep within a sample. This is because it reduces the influence of nonuniformity caused by the spectrometer and is unaffected by distortion due to interpolation.

© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Tetsuya Uchida ; Yuya Inuzuka ; Masaya Hasegawa ; Shigeki Hirobayashi and Tadanobu Misawa
"Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography", Opt. Eng. 54(3), 033108 (Mar 25, 2015). ; http://dx.doi.org/10.1117/1.OE.54.3.033108


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