OE Letters

Video-rate volumetric optical coherence tomography-based microangiography

[+] Author Affiliations
Utku Baran, Wei Wei, Jingjiang Xu, Xiaoli Qi, Ruikang K. Wang

University of Washington, College of Engineering, Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195-5061, United States

Wyatt O. Davis

Microvision Inc., 6244 185th Avenue NE, Redmond, Washington 98052, United States

Opt. Eng. 55(4), 040503 (Apr 26, 2016). doi:10.1117/1.OE.55.4.040503
History: Received March 10, 2016; Accepted April 7, 2016
Text Size: A A A

Abstract.  Video-rate volumetric optical coherence tomography (vOCT) is relatively young in the field of OCT imaging but has great potential in biomedical applications. Due to the recent development of the MHz range swept laser sources, vOCT has started to gain attention in the community. Here, we report the first in vivo video-rate volumetric OCT-based microangiography (vOMAG) system by integrating an 18-kHz resonant microelectromechanical system (MEMS) mirror with a 1.6-MHz FDML swept source operating at 1.3  μm wavelength. Because the MEMS scanner can offer an effective B-frame rate of 36 kHz, we are able to engineer vOMAG with a video rate up to 25 Hz. This system was utilized for real-time volumetric in vivo visualization of cerebral microvasculature in mice. Moreover, we monitored the blood perfusion dynamics during stimulation within mouse ear in vivo. We also discussed this system’s limitations. Prospective MEMS-enabled OCT probes with a real-time volumetric functional imaging capability can have a significant impact on endoscopic imaging and image-guided surgery applications.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Utku Baran ; Wei Wei ; Jingjiang Xu ; Xiaoli Qi ; Wyatt O. Davis, et al.
"Video-rate volumetric optical coherence tomography-based microangiography", Opt. Eng. 55(4), 040503 (Apr 26, 2016). ; http://dx.doi.org/10.1117/1.OE.55.4.040503


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.