The effect of increasing on image interpretability is explored, and the fidelity of general image quality equation (GIQE) predictions is assessed for Nyquist-sampled () imagery at low signal-to-noise ratio. A digital image chain simulation is developed and validated against a laboratory test bed using objective and subjective assessments. Using the validated model, additional test cases are simulated to study the effects of increased detector sampling on image quality with operational considerations for space-based remote sensing. Variants of the GIQE are evaluated against subject-provided ratings, and modifications that increase prediction accuracy for imagery are proposed. Finally, using the validated simulation and modified image quality equation, trades are conducted to ascertain the feasibility of implementing designs in future electro-optical systems.