A multipoint fiber optic sensor based on two cascaded multimode interferometer (MMI) and fiber Bragg grating (FBG) structures is proposed and demonstrated for simultaneous measurement of refractive index (RI) and temperature. The MMI is fabricated by splicing a section of no-core fiber (NCF) with two single-mode fibers. The suitable NCF lengths of 19.1 and 38.8 mm are selected by simulations to achieve wavelength division multiplexing. The two MMIs are sensitive to RI and temperature with the maximal RI sensitivities of 429.42228 and in the range of 1.333 to 1.419 and the temperature sensitivities of 10.05 and in the range of 26.4°C to 100°C, respectively. However, the FBGs are only sensitive to the latter with the sensitivities of 10.4 and . Therefore, dual-parameter measurement is obtained and cross-sensitivity issue can be solved. The distance between the two sensing heads is up to 12 km, which demonstrates the feasibility of long-distance measurement. During measurement, there is no mutual interference to each sensing head. The experimental results show that the average errors of RI are and and the average errors of temperature are 0.017°C and 0.012°C, respectively. This sensor exhibits the advantages of high RI sensitivity, dual-parameter and long-distance measurement, low cost, and easy and repeatable fabrication.