Imaging Components, Systems, and Processing

Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging

[+] Author Affiliations
Liang Li, Siyuan Zhang, Ruizhe Li, Zhiqiang Chen

Tsinghua University, Department of Engineering Physics, Beijing, China

Tsinghua University, Ministry of Education, Key Laboratory of Particle and Radiation Imaging, Beijing, China

Opt. Eng. 56(4), 043106 (Apr 20, 2017). doi:10.1117/1.OE.56.4.043106
History: Received December 8, 2016; Accepted April 5, 2017
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Abstract.  X-ray fluorescence computed tomography (XFCT) was performed on a high-intensity synchrotron radiation source or a pencil beam with a long exposure time due to the low emission and detection efficiency of x-ray fluorescence photons. For the first time, the feasibility and experimental results of a full-field fan-beam XFCT with a photon-counting detector array are presented. This full-field fan-beam XFCT consists of a conventional low-intensity x-ray tube, an energy-sensitive photon-counting detector array, and a tungsten pinhole collimator. A phantom containing gadolinium solution (Kα, 42.74 keV) was scanned for 30 min using a polychromatic x-ray fan beam with a third-generation computed tomography (CT) geometry. After scattering and attenuation corrections, experimental results showed that XFCT had better accuracy and performance than spectral CT. Full-field XFCT is a promising modality for biomedical imaging of exogenous molecular probes containing nanoparticles of high atomic number.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Liang Li ; Siyuan Zhang ; Ruizhe Li and Zhiqiang Chen
"Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging", Opt. Eng. 56(4), 043106 (Apr 20, 2017). ; http://dx.doi.org/10.1117/1.OE.56.4.043106


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