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7 March 2022 Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light
Michael Singh, Alex Vitkin
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Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC119630G (2022) https://doi.org/10.1117/12.2608925
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Precancer-to-cancer progression in epithelial tissues is marked by cellular proliferation and nuclear pleomorphism. These transformations have been shown to influence tissue optical properties: (1) tissue turbidity (quantified by the scattering coefficient) and (2) average scatterer size. It is found that backscattered polarized light can assess these properties. We use linear and circular depolarization to generate a predictive response surface where turbid media samples cluster by scatterer size and scattering coefficient. The novel polarimetric ability to noninvasively and simultaneously assess scatterer size and scattering coefficient of tissue-like turbid media may improve upon currently invasive skin cancer tests.
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Michael Singh and Alex Vitkin "Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC119630G (7 March 2022); https://doi.org/10.1117/12.2608925
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KEYWORDS
Scattering
Light scattering
Polarization
Tissues
Backscatter
Polarimetry
Photon polarization
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