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Real-time collection and detection are crucial to mitigate airborne biothreats as evidenced during the COVID-19 pandemic. Herein, we numerically and experimentally demonstrate the collection and enrichment of aerosolized polystyrene microparticles using stratified air-water flow in U-shaped and spiral microchannels. Collection efficiencies calculated from multiphase flow simulations show good agreement with the experiment data. The U-shaped channel demonstrates poor particle capture efficiency for submicron particles. To aid this, a two-stage spiral microchannel is designed and fabricated, which shows a 60% higher average particle capture efficiency for submicron particles. Thus, the microchannels enable enrichment and capture of microparticles in sensing-ready solutions.
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