Free space ultrasound guided fluorescence diffuse optical tomography

Pei-An Lo; Huihua Kenny Chiang

doi:10.1117/12.2249964

3 March 2017 Free space ultrasound guided fluorescence diffuse optical tomography

Pei-An Lo, Huihua Kenny Chiang

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100643L (2017) https://doi.org/10.1117/12.2249964
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In this study, a novel imaging modality, free space guided fluorescence diffuse optical tomography (FDOT), was perform to reconstruct the fluorophore distribution by incorporate structural priors into optical image inversion schemes. The dual modality imaging system used a rotation gantry combined with an electron-multiplying charge-coupled device (EMCCD) and a laser source in trans-illumination mode. The fluorescence data was collected from 360° range. The structural information of the object were obtained by an ultrasound linear array transducer. To validate the performance of the system, phantoms and bio tissue experiment were conducted. The results show that the imaging system achieves accurate and has the potential for further in vivo study.

Citation Download Citation

Pei-An Lo and Huihua Kenny Chiang "Free space ultrasound guided fluorescence diffuse optical tomography", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100643L (3 March 2017); https://doi.org/10.1117/12.2249964

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KEYWORDS

Ultrasonography

Luminescence

Imaging systems

Diffuse optical tomography

Tissue optics

Tissues

Transducers

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