Optical clearing of vaginal tissues in cadavers

Chun-Hung Chang; Luke A. Hardy; Michael G. Peters; Dina A. Bastawros; Erinn M. Myers; Michael J. Kennelly; Nathaniel M. Fried

doi:10.1117/12.2285079

7 February 2018 Optical clearing of vaginal tissues in cadavers

Chun-Hung Chang, Luke A. Hardy, Michael G. Peters, Dina A. Bastawros, Erinn M. Myers, Michael J. Kennelly, Nathaniel M. Fried

Author Affiliations +

Proceedings Volume 10468, Therapeutics and Diagnostics in Urology 2018; 104680K (2018) https://doi.org/10.1117/12.2285079
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

A nonsurgical laser procedure is being developed for treatment of female stress urinary incontinence (SUI). Previous studies in porcine vaginal tissues, ex vivo, as well as computer simulations, showed the feasibility of using near-infrared laser energy delivered through a transvaginal contact cooling probe to thermally remodel endopelvic fascia, while preserving the vaginal wall from thermal damage. This study explores optical properties of vaginal tissue in cadavers as an intermediate step towards future pre-clinical and clinical studies. Optical clearing of tissue using glycerol resulted in a 15-17% increase in optical transmission after 11 min at room temperature (and a calculated 32.5% increase at body temperature). Subsurface thermal lesions were created using power of 4.6 - 6.4 W, 5.2-mm spot, and 30 s irradiation time, resulting in partial preservation of vaginal wall to 0.8 - 1.1 mm depth.

Citation Download Citation

Chun-Hung Chang, Luke A. Hardy, Michael G. Peters, Dina A. Bastawros, Erinn M. Myers, Michael J. Kennelly, and Nathaniel M. Fried "Optical clearing of vaginal tissues in cadavers", Proc. SPIE 10468, Therapeutics and Diagnostics in Urology 2018, 104680K (7 February 2018); https://doi.org/10.1117/12.2285079

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KEYWORDS

Tissues

Optical coherence tomography

Optical clearing

Laser therapeutics

Spectroscopy

Tissue optics

Laser energy

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