Skin lesion imaging with line-field confocal optical coherence tomography

Maxime Cazalas; Olivier Levecq; Hicham Azimani; David Siret; Anaïs Barut; Marianno Suppa; Véronique del Marmol; Josep Malvehy; Elisa Cinotti; Pietro Rubegni; Jean Luc Perrot; Arnaud Dubois

doi:10.1117/12.2508484

26 February 2019 Skin lesion imaging with line-field confocal optical coherence tomography

Maxime Cazalas, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, Marianno Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Arnaud Dubois

Author Affiliations +

Proceedings Volume 10851, Photonics in Dermatology and Plastic Surgery 2019; 108510M (2019) https://doi.org/10.1117/12.2508484
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

An improved optical coherence tomography (OCT) technique called line-field confocal OCT (LC-OCT) has been developed for high-resolution skin imaging. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of ∼ 1 μm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo, at the cellular level down to a depth of ∼ 500 μm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to well correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions.

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Maxime Cazalas, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, Marianno Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, and Arnaud Dubois "Skin lesion imaging with line-field confocal optical coherence tomography", Proc. SPIE 10851, Photonics in Dermatology and Plastic Surgery 2019, 108510M (26 February 2019); https://doi.org/10.1117/12.2508484

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