Effects of probe parameters on photobiomdulation therapy for spinal cord injury: a numerical algorithm modelling study

Ali Shuaib; Ali K. Bourisly

doi:10.1117/12.2508719

7 March 2019 Effects of probe parameters on photobiomdulation therapy for spinal cord injury: a numerical algorithm modelling study

Ali Shuaib, Ali K. Bourisly

Author Affiliations +

Proceedings Volume 10861, Mechanisms of Photobiomodulation Therapy XIV; 108610J (2019) https://doi.org/10.1117/12.2508719
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Photobiomodulation therapy (PBMT) has demonstrated efficacy in various areas of medical practice including pain management, wound healing, inflammation treatment, and treatment for neurological diseases. More recently, animal model studies have reported that near-infrared light irradiation to a spinal cord injury (SCI) site transcutaneously enhances axonal regeneration and functional recovery. Many such studies typically use a variety of irradiation parameters and surface irradiance to calculate the fluence delivered to the injury site, and many times ignoring factors such as tissue optical properties, beam divergence, beam positioning, and tissue thickness to the organ of interest. While these studies show a broad range of treatment outcomes, a comparison of treatment efficacy among these studies with respect to light fluence is many times extremely difficult. Therefore in this study, we use Monte Carlo simulation to provide an overview of the effect of the light source probe parameters and positioning on an injury site using a 3D voxelated SCI rat phantom model with regards to PBMT. In this study, an 810 nm Top-hat beam was simulated for 3 numerical apertures (NA) (0, 0.4, and 0.8), 5 beam diameters (0.04, 0.1, 0.2, 0.4, and 0.8 cm), and 14 different irradiation positions relative to the SCI injury site. Our findings are beneficial for research into understanding the effects of the probe parameters on tissues and organs, which ultimately will aid in reducing the variability in the used fluence and help optimize PBMT outcomes.

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Ali Shuaib and Ali K. Bourisly "Effects of probe parameters on photobiomdulation therapy for spinal cord injury: a numerical algorithm modelling study", Proc. SPIE 10861, Mechanisms of Photobiomodulation Therapy XIV, 108610J (7 March 2019); https://doi.org/10.1117/12.2508719

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KEYWORDS

Injuries

Spinal cord

3D modeling

Monte Carlo methods

Tissues

Animal model studies

Optical properties

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