Speckle based sensing of chemicals by an acoustic excitation in aqueous solutions

Hadar Genish; Nisan Ozana; Zeev Zalevsky

doi:10.1117/12.2511594

7 March 2019 Speckle based sensing of chemicals by an acoustic excitation in aqueous solutions

Hadar Genish, Nisan Ozana, Zeev Zalevsky

Proceedings Volume 10895, Frontiers in Biological Detection: From Nanosensors to Systems XI; 108950K (2019) https://doi.org/10.1117/12.2511594
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The optical activity of glucose in aqueous solutions offers a very high specificity in detecting the presence of glucose. In this presentation we will present several concepts for non-invasive detection of glucose, being realized in-vitro as well as in-vivo. In all cases the sensing concept is based upon analysis of time changing spatial statistics of back scattered speckle patterns when being analyzed by properly defocused optics. We will focus on an experimental approach in which we try to employ contactless measurement of acoustic excitations in solutions containing various chemical while using analysis of those time changing speckle pattern. Solutions containing glucose should response differently than those where glucose is absent. To perform this measurement, we excited acoustic waves in a solution and measured the changes in the speckle pattern. The basic concept is that while the solution is acoustically excited the acoustic waves modulate the density of the fluid under examination. This modulation will have two effects on the speckle pattern, the first is a spatial and time-varying modulation of the effective refractive index, and the second is a spatial and time-varying modulation of the optical rotation which is induced by the presence of glucose. Both of these effects should change the speckle pattern, which if recorded with an exposure time which is longer than the acoustic period, will be seen as a smearing of the pattern. By analyzing properties such as speckle size, contrast and/or correlation between images, it is possible to extract a signal which is proportional to the amplitude of the acoustic excitation.

Citation Download Citation

Hadar Genish, Nisan Ozana, and Zeev Zalevsky "Speckle based sensing of chemicals by an acoustic excitation in aqueous solutions", Proc. SPIE 10895, Frontiers in Biological Detection: From Nanosensors to Systems XI, 108950K (7 March 2019); https://doi.org/10.1117/12.2511594

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Acoustics

Glucose

Speckle pattern

Speckle

Ferroelectric materials

Modulation

Chemical analysis

Show All Keywords

Keywords/Phrases

Search In:

Publication Years