Estimation of the advanced glycation end products accumulated by sclera using autofluorescence

Vladimir N. Grishanov; Dmitriy V. Kornilin; Igor V. Malov; Georgiy A. Pleshakov

doi:10.1117/12.2581897

10 October 2020 Estimation of the advanced glycation end products accumulated by sclera using autofluorescence

Vladimir N. Grishanov, Dmitriy V. Kornilin, Igor V. Malov, Georgiy A. Pleshakov

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 115532Z (2020) https://doi.org/10.1117/12.2581897
Event: SPIE/COS Photonics Asia, 2020, Online Only

Conference Poster

Abstract

Evaluation of the concentration of glycation end products (AGE) in the human body utilizing autofluorescence is widely used in medical practice. The autofluorescence level is usually measured from the skin of the hand. However, this measurement can hardly be used for some of the human skin phototypes. On the other hand, the sclera of the eye also consists of collagen fibers that can be affected by glycation. Sclera autofluorescence can also be investigated in vivo by "hand-held" fluorescence meter. In this case, there are no effects of the skin phototype and no effect of pressure made by the hand on the fluorescence meter. Therefore, the study of correlation between the fluorescence of the skin of the hand and the sclera fluorescence is in the area of practical interest. In this research the results of the simultaneous measurements of skin and sclera autofluorescence made on 34 humans are presented. The "hand-held" fluorescence meter and an upgraded slit lamp were used as instruments. The value of the Pearson correlation coefficient was 0.89, which can be considered as successful validation of using fluorescence for assessment of the AGE content in the sclera.

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Vladimir N. Grishanov, Dmitriy V. Kornilin, Igor V. Malov, and Georgiy A. Pleshakov "Estimation of the advanced glycation end products accumulated by sclera using autofluorescence", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115532Z (10 October 2020); https://doi.org/10.1117/12.2581897

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