High-sensitivity multi-speckle diffuse correlation spectroscopy

Edbert Sie; Hui Chen; E-Fann Saung; Ryan Catoen; Tobias Tiecke; Mark Chevillet; Francesco Marsili

doi:10.1117/12.2578058

5 March 2021 High-sensitivity multi-speckle diffuse correlation spectroscopy

Edbert Sie, Hui Chen, E-Fann Saung, Ryan Catoen, Tobias Tiecke, Mark Chevillet, Francesco Marsili

Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410L (2021) https://doi.org/10.1117/12.2578058
Event: SPIE BiOS, 2021, Online Only

Abstract

Cerebral blood flow is an important biomarker of brain health and function, as it regulates the delivery of oxygen and substrates to tissue and the removal of metabolic waste products. Diffuse Correlation Spectroscopy (DCS) is a promising noninvasive optical technique for monitoring cerebral blood flow and for measuring cortex functional activation tasks. However, the current state-of-the-art DCS adoption is hindered by a trade-off between sensitivity to the cortex and signal-to-noise ratio (SNR). Here we report on a multi-speckle DCS (mDCS) system based on a 1024-pixel single-photon avalanche diode (SPAD) camera that removes this trade-off and demonstrated a 32-fold increase in SNR with respect to traditional single-speckle DCS.

Conference Presentation

Citation Download Citation

Edbert Sie, Hui Chen, E-Fann Saung, Ryan Catoen, Tobias Tiecke, Mark Chevillet, and Francesco Marsili "High-sensitivity multi-speckle diffuse correlation spectroscopy", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410L (5 March 2021); https://doi.org/10.1117/12.2578058

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