Super-resolution lensless microscopy using multi-wavelength multiplexing

Xuejuan Wu; Jialin Zhang; Jiasong Sun; Linpeng Lu; Qian Chen; Chao Zuo

doi:10.1117/12.2586569

15 January 2021 Super-resolution lensless microscopy using multi-wavelength multiplexing

Xuejuan Wu, Jialin Zhang, Jiasong Sun, Linpeng Lu, Qian Chen, Chao Zuo

Proceedings Volume 11761, Fourth International Conference on Photonics and Optical Engineering; 117611X (2021) https://doi.org/10.1117/12.2586569
Event: Fourth International Conference on Photonics and Optical Engineering, 2020, Xi'an, China

Abstract

We report a multi-wavelength multiplexed setup and associated super-resolution reconstruction method in lensless microscopy, which can generate high-resolution reconstructions from undersampled raw measurements captured at multiple wavelengths. The reconstruction result of the Benchmark Quantitative Phase Microscopy Target (QPT^TM) demonstrates the resolution enhancement quantitatively, which achieves a half-pitch lateral resolution of 691 nm across a large field of view (~29.85 mm2), surpassing 2.41 times of the theoretical NyquistShannon sampling resolution limit imposed by the pixel-size of the sensor (1.67 µm). Compared with other superresolution methods such as lateral or axial shift-based device and illumination source rotation design, wavelength multiplexed avoids the need for shifting/rotating mechanical components. This multi-wavelength multiplexed super-resolution method would benet the research and development of a more stable lensless microscopy system.

Citation Download Citation

Xuejuan Wu, Jialin Zhang, Jiasong Sun, Linpeng Lu, Qian Chen, and Chao Zuo "Super-resolution lensless microscopy using multi-wavelength multiplexing", Proc. SPIE 11761, Fourth International Conference on Photonics and Optical Engineering, 117611X (15 January 2021); https://doi.org/10.1117/12.2586569

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