Quantification of tissue blood flow and scattering coefficient by diffusion correlation spectroscopy

Minnan Jiang; Zhe Li; Kebin Jia; Jie De; Jinchao Feng; Qisi Ge

doi:10.1117/12.2606951

24 November 2021 Quantification of tissue blood flow and scattering coefficient by diffusion correlation spectroscopy

Minnan Jiang, Zhe Li, Kebin Jia, Jie De, Jinchao Feng, Qisi Ge

Proceedings Volume 12067, AOPC 2021: Biomedical Optics; 120670G (2021) https://doi.org/10.1117/12.2606951
Event: Applied Optics and Photonics China 2021, 2021, Beijing, China

Abstract

Traditionally, diffuse correlation spectroscopy (DCS) derives blood flow (BF) by measuring of the temporal intensity fluctuations of multiply scattered light from a single source-detector pair. In this paper, a multi-wavelength DCS approach was proposed to quantify tissue blood flow and scattering coefficient based on long short-term memory (LSTM) architecture. Phantom experiments were established to measure normalized intensity autocorrelation function data by multi-wavelength DCS system at different velocities and scattering coefficients. The results support the notion of using proposed LSTM architecture for quantification of blood flow and scattering coefficient in DCS.

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Minnan Jiang, Zhe Li, Kebin Jia, Jie De, Jinchao Feng, and Qisi Ge "Quantification of tissue blood flow and scattering coefficient by diffusion correlation spectroscopy", Proc. SPIE 12067, AOPC 2021: Biomedical Optics, 120670G (24 November 2021); https://doi.org/10.1117/12.2606951

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KEYWORDS

Scattering

Blood circulation

Liquids

Spectroscopy

Tissue optics

Diffusion

Tissues

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