Investigating cerebral dynamics during cardiac arrest using an optical technique and a hemodynamic model

Nima Khalifehsoltani; Vladislav Toronov; Olivia Rennie; Rohit Mohindra; Steve Lin

doi:10.1117/12.3001979

12 March 2024 Investigating cerebral dynamics during cardiac arrest using an optical technique and a hemodynamic model

Nima Khalifehsoltani, Vladislav Toronov, Olivia Rennie, Rohit Mohindra, Steve Lin

Proceedings Volume 12841, Dynamics and Fluctuations in Biomedical Photonics XXI; 1284104 (2024) https://doi.org/10.1117/12.3001979
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Hemodynamic models connect cerebral blood flow and oxygen metabolism with deoxy-hemoglobin and oxyhemoglobin measured by near-infrared spectroscopy (NIRS) to analyze cerebral hemodynamics. These models elucidate the relationship between physiological processes and NIRS signals, capturing changes in cerebral blood volume, flow, and oxygen metabolism. In our study, we explore microvasculature compartments and apply these models to NIRS data during pig cardiac arrest and cardiopulmonary resuscitation. Our goals were to validate the model and to understand the behavior of cerebral microvasculature and metabolism during cardiac arrest and resuscitation. By employing the inverse of the hemodynamic model, we measure a range of significant physiological parameters.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Nima Khalifehsoltani, Vladislav Toronov, Olivia Rennie, Rohit Mohindra, and Steve Lin "Investigating cerebral dynamics during cardiac arrest using an optical technique and a hemodynamic model", Proc. SPIE 12841, Dynamics and Fluctuations in Biomedical Photonics XXI, 1284104 (12 March 2024); https://doi.org/10.1117/12.3001979

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