Chronic effects in temperature-controlled application of MRI-monitored interstitial laser therapy

Keyvan Farahani; Robert B. Lufkin; Frank G. Shellock; Sharon Hirschowitz; Dan J. Castro

doi:10.1117/12.147687

7 July 1993 Chronic effects in temperature-controlled application of MRI-monitored interstitial laser therapy

Keyvan Farahani, Robert B. Lufkin, Frank G. Shellock, Sharon Hirschowitz, Dan J. Castro

Proceedings Volume 1882, Laser-Tissue Interaction IV; (1993) https://doi.org/10.1117/12.147687
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The goal of interstitial laser therapy is to destroy neoplastic tissue through localized heating. Temperature elevations to the necrotic coagulation threshold of about 60 degree(s)C cause the induction of irreversible, as well as, reversible alterations to tissues. While chronic effects prevail days following the treatment, the relevant issue from the perspective of magnetic resonance imaging-monitoring of laser therapy, is the ability of MRI in detecting these effects. In this study time-course MRI images of rabbit musculature, treated with 'temperature controlled' Nd:YAG laser irradiation were correlated with histological changes. The MRI appearance of the interstitial laser lesion can be divided into three categories of acute, sub- acute, and chronic. The dynamics of chronic lesion development, including variations in shape, size and composition of the lesion were successfully documented by T2-weighted spin echo MRI.

Citation Download Citation

Keyvan Farahani, Robert B. Lufkin, Frank G. Shellock, Sharon Hirschowitz, and Dan J. Castro "Chronic effects in temperature-controlled application of MRI-monitored interstitial laser therapy", Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); https://doi.org/10.1117/12.147687

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