LEDs in frequency domain spectroscopy of tissues

Maria-Angela Franceschini; Sergio Fantini; Enrico Gratton

doi:10.1117/12.176004

19 May 1994 LEDs in frequency-omain spectroscopy of tissues

Maria-Angela Franceschini, Sergio Fantini, Enrico Gratton

Proceedings Volume 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases; (1994) https://doi.org/10.1117/12.176004
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Light spectroscopy in the frequency-domain has been used to study the optical properties of biological tissues. We have analyzed the possibility of using LEDs as intensity modulated light sources for frequency-domain spectroscopy. The use of LEDs presents several advantages: one LED's output covers a spectral region of about 80 nm, and commercially available LEDs allow for the coverage of the spectral range from 550 to 900 nm, which is a region of interest in near-IR medical applications; the light output of an LED is stable with respect to that of lasers and lamps; the wide angular distribution make LEDs safe for in vivo studies. Furthermore, LED frequency-domain spectroscopy is a relatively inexpensive technique. We describe some circuits we used to modulate the intensity of LEDs at radio frequency, and point out the possibility of building a multisource spectrometer. Some applications of LED frequency-domain spectroscopy, both in vitro and in vivo, are shown.

Citation Download Citation

Maria-Angela Franceschini, Sergio Fantini, and Enrico Gratton "LEDs in frequency-omain spectroscopy of tissues", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); https://doi.org/10.1117/12.176004

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