Effect of sulfonation on photodynamic inactivation of living cells by aluminum phthalocyanines

Marina Yu. Poroshina; Elena B. Chernyaeva; Jan Greve; A. G.J.M. Van Leeuwen; Gerwin J. Puppels

doi:10.1117/12.197460

2 January 1995 Effect of sulfonation on photodynamic inactivation of living cells by aluminum phthalocyanines

Marina Yu. Poroshina, Elena B. Chernyaeva, Jan Greve, A. G.J.M. Van Leeuwen, Gerwin J. Puppels

Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995) https://doi.org/10.1117/12.197460
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus

Abstract

During the last decade a new modality of cancer treatment appeared, called photodynamic therapy (PDT). This treatment is based on the following observation. Some dyes, administered intravenously, are preferentially retained in solid tumors as a result of as yet incompletely understood properties of malignant tissue. Subsequent exposure to light of a wavelength that is absorbed by the dye initiates a chain of events that ends in tumor necrosis. Recent results have demonstrated the considerable potential of phthalocyanines. The sulfonated derivatives of phthalocyanine metal complexes (MeS_nPc) have been proposed for the photodynamic therapy since they demonstrate good efficiency of phototoxicity, are water-soluble and have a low level of dark toxicity. It was already reported that the sulfonation degree influences the photodynamic activity of MeS_nPc³. The present work was undertaken to investigate some parameters that determine the photodynamic effect for aluminum phthalocyanines with different degree of sulfonation.

Citation Download Citation

Marina Yu. Poroshina, Elena B. Chernyaeva, Jan Greve, A. G.J.M. Van Leeuwen, and Gerwin J. Puppels "Effect of sulfonation on photodynamic inactivation of living cells by aluminum phthalocyanines", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); https://doi.org/10.1117/12.197460

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