Photodynamic therapy of head and neck cancer with different sensitizers

Elena G. Vakoulovskaya M.D.; Victor V. Shental M.D.; N. A. Abdoullin; Yury P. Kuvshinov; T. D. Tabolinovskaia; N. J. Edinak; Boris K. Poddubny; T. T. Kondratjeva; Gennadii A. Meerovich; Alexander A. Stratonnikov; Kirill G. Linkov; Valery V. Agafonov

doi:10.1117/12.297809

29 December 1997 Photodynamic therapy of head and neck cancer with different sensitizers

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., N. A. Abdoullin, Yury P. Kuvshinov, T. D. Tabolinovskaia, N. J. Edinak, Boris K. Poddubny, T. T. Kondratjeva, Gennadii A. Meerovich, Alexander A. Stratonnikov, Kirill G. Linkov, Valery V. Agafonov

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297809
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

This paper deals with the results of clinical trials for sulfated aluminum phthalocyanine (PHS) (Photosens, Russia) and Photogeme (PG) in Russia. The results of photodynamic therapy (PDT) of head and neck tumors (HNT), side effects and ways of their correction and prevention, as well as possibility to work out less toxic regimes of PDT with photosense, choice of laser and type of irradiation are discussed. PDT have been provided in 79 patients with different head and neck tumors. Efficacy of PDT depended on tumor size and its histological type. Undesirable changes in plasma content of antioxidants by means of high pressure liquid chromatography (HLPC) have been found in patients after PHS injection. Influence of short-term and long-term supplementation with beta-carotene and vitamin E on this parameters are discussed.

Citation Download Citation

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., N. A. Abdoullin, Yury P. Kuvshinov, T. D. Tabolinovskaia, N. J. Edinak, Boris K. Poddubny, T. T. Kondratjeva, Gennadii A. Meerovich, Alexander A. Stratonnikov, Kirill G. Linkov, and Valery V. Agafonov "Photodynamic therapy of head and neck cancer with different sensitizers", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297809

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