Holographic Measurement Of Particulate Contamination In Sealed Sterile Containers

John C. Zeiss; Julius Z. Knapp; Joe S. Crane; Paul Dunn; Brian J . Thompson

doi:10.1117/12.933957

7 July 1983 Holographic Measurement Of Particulate Contamination In Sealed Sterile Containers

John C. Zeiss, Julius Z. Knapp, Joe S. Crane, Paul Dunn, Brian J . Thompson

Proceedings Volume 0353, Industrial and Commercial Applications of Holography; (1983) https://doi.org/10.1117/12.933957
Event: 26th Annual Technical Symposium, 1982, San Diego, United States

Abstract

The presence of particulates, in injectable: solutions, can be medically hazardous depending on their size and shape. Hence, a. mandatory particulate inspection is performed prior to the release of any injectable drug. However, the determination of realistic quality limits, has been hampered by the absence of any physical non-destructive, measurement or comparison technique. This paper describes a far-field holographic' method for the measurement of particulate, contamination in sealed sterile containers. This application of holography provides to the pharmaceutical industry for the first. time, a non-destructive technique to inspect production containers and to classify the size and quantity of contaminants.

Citation Download Citation

John C. Zeiss, Julius Z. Knapp, Joe S. Crane, Paul Dunn, and Brian J . Thompson "Holographic Measurement Of Particulate Contamination In Sealed Sterile Containers", Proc. SPIE 0353, Industrial and Commercial Applications of Holography, (7 July 1983); https://doi.org/10.1117/12.933957

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