Mechanism of laser immunotherapy: role of immunoadjuvant and selective photothermal laser-tissue interaction

Wei R. Chen; Hong Liu; Robert E. Nordquist

doi:10.1117/12.462529

12 April 2002 Mechanism of laser immunotherapy: role of immunoadjuvant and selective photothermal laser-tissue interaction

Wei R. Chen, Hong Liu, Robert E. Nordquist

Author Affiliations +

Proceedings Volume 4536, International Workshop on Photonics and Imaging in Biology and Medicine; (2002) https://doi.org/10.1117/12.462529
Event: International Workshop on Photonics and Imaging in Biology and Medicine, 2001, Wuhan, China

Abstract

Immunotherapy has been used for cancer treatment in the past century. Although different approaches have been attempted, the basic strategy has been targeting specific tumor antigens to induce host immune responses. Laser immunotherapy is a novel approach in treating metastatic tumors. The combination of two major interactions in laser immunotherapy - selective photothermal and photoimmunological interactions - is designed to induce a tumor-specific host immune response. The hypothetical mechanism is as follows. The intratumor injection of laser- absorbing dye and the noninvasive irradiation of a near- infrared laser produce an acute, selective thermal tumor killing, and at the same time, release tumor antigens. The in-situ immunoadjuvant then combines with the liberated tumor antigens to stimulate and direct the host immune system to fight against remaining tumor cells both locally and in remote metastatic sites. In effect, an in-situ vaccination against the tumor was achieved. Such an immune response eventually leads to a systemic, long-term tumor resistance. Our pre-clinical animal studies have demonstrated such a long-term immunity. Specifically, a novel immunoadjuvant, glycated chitosan (GC), was used in laser immunotherapy. Because the use of immunoadjuvant is crucial in cancer immunotherapy, the role of GC was investigated.

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Wei R. Chen, Hong Liu, and Robert E. Nordquist "Mechanism of laser immunotherapy: role of immunoadjuvant and selective photothermal laser-tissue interaction", Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); https://doi.org/10.1117/12.462529

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