The potential of spectral imaging in the noninvasive diagnostics of tissue cancers and precancers

Costas J. Balas

doi:10.1117/12.517034

8 August 2003 The potential of spectral imaging in the noninvasive diagnostics of tissue cancers and precancers

Costas J. Balas

Proceedings Volume 5123, Advanced Optical Devices, Technologies, and Medical Applications; (2003) https://doi.org/10.1117/12.517034
Event: 2003 Chapter books, 2003, Bellingham, WA, United States

Abstract

A novel approach to the problem of non-invasive diagnostics is presented, which relay son a combiend optical and chemical excitation of the tissue, by employing white light and topical application of acetic acid solution, respecitvley. Acetic acid-tissue interaction results in a transient alteration in the light scattering properties of the abnormal tissue selectivity. A specially developed Spectral Imaging system was used for the in vivo spectral imaging and analysis of the tissue and for the measurement, as a function of both time and location, of the acetic acid-induced alterations in the tissue scattering properties. Modeling and fitting of the experimental data result in the calculation of the kinetic constants of the marker-tissue interaction process, and spatil distribution of whcih is visualized with the aid of a pseudocolor scale. Clinical evaluation of both methodology and technology in normal, precancerous and cancerous lesions of cervix show that the measured kinetic data contain specific information, which enables the differentiation between cancerous and non-cancerous lesions, as well as between dysplasias of different grade. The calculated map of the kinetic constants provides information for the spatial distribution of the lesion's grades, thus enabling the detection of incipient lesions and the precise localization and classification of pathologic tissue areas.

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Costas J. Balas "The potential of spectral imaging in the noninvasive diagnostics of tissue cancers and precancers", Proc. SPIE 5123, Advanced Optical Devices, Technologies, and Medical Applications, (8 August 2003); https://doi.org/10.1117/12.517034

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KEYWORDS

Tissues

Tissue optics

Imaging spectroscopy

Diagnostics

Imaging systems

Light scattering

In vivo imaging

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