Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue macroachitecture in normal and precancerous states

Young L. Kim; Yang Liu; Ramesh K. Wali; Hemant J. Roy M.D.; Michael J. Goldberg M.D.; Alexey K. Kromin; Kun Chen; Vadim Backman

doi:10.1117/12.500880

8 October 2003 Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue macroachitecture in normal and precancerous states

Young L. Kim, Yang Liu, Ramesh K. Wali, Hemant J. Roy M.D., Michael J. Goldberg M.D., Alexey K. Kromin, Kun Chen, Vadim Backman

Author Affiliations +

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500880
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting" can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.

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Young L. Kim, Yang Liu, Ramesh K. Wali, Hemant J. Roy M.D., Michael J. Goldberg M.D., Alexey K. Kromin, Kun Chen, and Vadim Backman "Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue macroachitecture in normal and precancerous states", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500880

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