Estimation of path length factor for measurement of haemoglobin concentration in the exposed cortical tissue

K. Sakaguchi; T. Tachibana; K. Yokoyama; S. Furukawa; T. Katsura; A. Maki; H. Kawaguchi; E. Okada

doi:10.1117/12.632848

7 October 2005 Estimation of path length factor for measurement of haemoglobin concentration in the exposed cortical tissue

K. Sakaguchi, T. Tachibana, K. Yokoyama, S. Furukawa, T. Katsura, A. Maki, H. Kawaguchi, E. Okada

Author Affiliations +

Proceedings Volume 5859, Photon Migration and Diffuse-Light Imaging II; 58590S (2005) https://doi.org/10.1117/12.632848
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

The change in oxy- and deoxy haemoglobin in the cortical tissue caused by brain function can be measured from multi-spectral images of exposed cortex. We cannot ignore the wavelength dependence of mean optical path length of detected light to calculate the accurate changes in concentrations of oxy- and deoxy- haemoglobin in the cortical tissue. The optical path length factor, which reflects the wavelength dependence of mean optical path length, is experimentally estimated from the multi-spectral images of exposed cortex of guinea pigs. The optical path length factor improves the accuracy in changes in concentrations of oxy- and deoxy-haemoglobin obtained from the multi-spectral images.

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K. Sakaguchi, T. Tachibana, K. Yokoyama, S. Furukawa, T. Katsura, A. Maki, H. Kawaguchi, and E. Okada "Estimation of path length factor for measurement of haemoglobin concentration in the exposed cortical tissue", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590S (7 October 2005); https://doi.org/10.1117/12.632848

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