Diagnose lung cancer by using fluorescence induce from small dose of hematoporphurin

Jing Zhu; Jian Xu; Lin Ke; Hui-Guo Zhang

doi:10.1117/12.639222

11 September 2006 Diagnose lung cancer by using fluorescence induce from small dose of hematoporphurin

Jing Zhu, Jian Xu, Lin Ke, Hui-Guo Zhang

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 59670X (2006) https://doi.org/10.1117/12.639222
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective: Diagnose lung tumor clinically by using fluorescence induced from small dose of hematoporphyrin. Method : 37 patients were diagnose in which 22 patients with tumor and 15 with non-tumor disease. The patients were intravenously injected small dose of HPD (2mg/kg). The fluorescence signal was analyzed with OMA system. Results: The fluorescence signal of low dose hematoporphyrin can use to diagnose cancer. The total of 37 patients, in which 22 patients suffered tumor, the average fluorescence peak of I_tumor/I_nomal was 1.24±0.08. We imitated a normal distributive curve, so that most ratio of I_tumor/I_nomal could be included in the scope of curve. Suppose the lower limit of diagnostic criterion was 1.05. accorded to the criterion 22 is tumor. 15 of them suffered non- tumor. The average of all I_tumor/I_nomal was 0.98±0.06, there is significant difference between normal and cancer. 13 of 15 is non-tumor, accorded to the criterion. The positive rate was 94.6%

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Jing Zhu, Jian Xu, Lin Ke, and Hui-Guo Zhang "Diagnose lung cancer by using fluorescence induce from small dose of hematoporphurin", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59670X (11 September 2006); https://doi.org/10.1117/12.639222

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