Multifunctional SMA-based smart inhaler system for improved aerosol drug delivery: design and fabrication

Matthew E. Pausley; Stefan Seelecke

doi:10.1117/12.776212

18 April 2008 Multifunctional SMA-based smart inhaler system for improved aerosol drug delivery: design and fabrication

Matthew E. Pausley, Stefan Seelecke

Proceedings Volume 6928, Active and Passive Smart Structures and Integrated Systems 2008; 69280T (2008) https://doi.org/10.1117/12.776212
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2008, San Diego, California, United States

Abstract

This paper documents the development of a prototype smart aerosol drug inhaler system using shape memory alloy (SMA) actuators. Unlike conventional dispersed-release inhalers, the smart inhaler system releases the aerosol drug in a very small area within the mouth inlet. Kleinstreuer and Zhang [1] have found that controlled release in the mouth inlet increases drug efficiency and allows targeting of specific sites within the lung. The methodology has been validated numerically and experimentally using fixed-exit position inhalers. The design presented in this work, however, allows for variation of nozzle exit position using SMA wire actuators in a combined actuator/sensor role. In contrast to other possible mechanisms, SMA wires are lightweight, require low power, and are the least obstructive to the flow of air through the inhaler. The dual actuator/sensor nature of the SMA wires (via resistance measurement) further simplifies the design. Solutions and insights into several SMA actuator design challenges are presented. SMA wire actuator characteristics such as achievable stroke and their effect on the design are highlighted. Consideration of actuator force requirements and the capabilities of SMA wires and studied. The problems posed by the thermal characteristics of SMA wires and innovative solutions are reported.

Citation Download Citation

Matthew E. Pausley and Stefan Seelecke "Multifunctional SMA-based smart inhaler system for improved aerosol drug delivery: design and fabrication", Proc. SPIE 6928, Active and Passive Smart Structures and Integrated Systems 2008, 69280T (18 April 2008); https://doi.org/10.1117/12.776212

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