The synthesis and application of two mesoporous silica nanoparticles as drug delivery system with different shape

Jiayi Wang; Zhuyuan Wang; Hui Chen; Shenfei Zong; Yiping Cui

doi:10.1117/12.2182147

4 May 2015 The synthesis and application of two mesoporous silica nanoparticles as drug delivery system with different shape

Jiayi Wang, Zhuyuan Wang, Hui Chen, Shenfei Zong, Yiping Cui

Author Affiliations +

Proceedings Volume 9543, Third International Symposium on Laser Interaction with Matter; 954318 (2015) https://doi.org/10.1117/12.2182147
Event: Third International Symposium on Laser Interaction with Matter, 2014, Jiangsu, China

Abstract

Mesoporous silica nanospheres(MSNSs) have been obtained utilizing the conventional reverse micelles synthesis method while the mesoporous silica nanorods(MSNRs) have been acquired by means of changing certain parameters. Afterwards, the prepared mesoporous silica nanospheres and nanorods were used as drug carriers to load and release the classical cancer therapeutic drug—DOX. According to the absorption spectra, the encapsulation efficiency of the mesoporous silica nanospheres is almost as high as that of the nanospheres. Different from the familiar encapsulation efficiency, the release characteristic curves of the mesoporous silica nanospheres and nanorods possessed certain differences during the release process. Finally incellular fluorescence imaging was achieved to observe the endocytosis of the mesoporous silica materials. Our results show that although both of the two kinds of nanoparticles possess favourable properties for loading and releasing drugs, the mesoporous silica nanospheres perform better in dispersity and controlled release than the nanorods, which probably endow them the potential as incellular drug delivery system.

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Jiayi Wang, Zhuyuan Wang, Hui Chen, Shenfei Zong, and Yiping Cui "The synthesis and application of two mesoporous silica nanoparticles as drug delivery system with different shape", Proc. SPIE 9543, Third International Symposium on Laser Interaction with Matter, 954318 (4 May 2015); https://doi.org/10.1117/12.2182147

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