In-vivo quantification of total hemoglobin concentrations with visible-light spectroscopic optical coherence tomography

Carlos Cuartas-Vélez; Nienke Bosschaart

doi:10.1117/12.2647239

9 March 2023 In-vivo quantification of total hemoglobin concentrations with visible-light spectroscopic optical coherence tomography

Carlos Cuartas-Vélez, Nienke Bosschaart

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670W (2023) https://doi.org/10.1117/12.2647239
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

In this work, we developed a methodology to non-invasively quantify total hemoglobin [tHb] concentrations in the microcirculation of the skin with visible-light spectroscopic optical coherence tomography (vis-sOCT). Our approach is based on the spatial distribution of [tHb] inside a vis-sOCT scan. Local [tHb] are retrieved by analyzing the optical density at each point of the tomogram. We show that the [tHb] distribution map, termed hemogram, presents blood vessel distributions comparable to that of optical coherence tomography angiography. In addition, we obtain a clinically useful measurement of the average [tHb] by analyzing the [tHb] across the hemogram. For a healthy volunteer, this average [tHb] of 11.62 g/dL falls within the expected clinical range and is consistent between eight independent measurement locations on the skin with a standard deviation of 0.88 g/dL.

Conference Presentation

Citation Download Citation

Carlos Cuartas-Vélez and Nienke Bosschaart "In-vivo quantification of total hemoglobin concentrations with visible-light spectroscopic optical coherence tomography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670W (9 March 2023); https://doi.org/10.1117/12.2647239

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