16 November 2018 Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation
Yi Sun, Haoyuan Cai, Xiaoping Wang
Author Affiliations +
Abstract
The throughput and label-free multianalyte interrogation ability provided by surface plasmon resonance imaging (SPRi) sensors has gained considerable interest in biochemical analysis. Here, we report an optical platform based on polarization contrast modulation, in which a three-dimensional plasmonic microwell array is used as a sensing chip to eliminate background resonance and greatly enhance the electromagnetic field response in the microwell structure by confining the SPR. In addition, the sensor can provide an extremely high contrast and signal-to-noise ratio and can achieve a very high sensitivity response (1.52  ×  105  pixel  /  RIU). Additionally, the signal-to-background ratio is improved to 40. The low-concentration limit of detection can reach 5.38  ×  10  −  7  RIU, which is 1 order of magnitude improvement. In biomolecular interaction analysis, the sensor can detect a 5.12  ×  104-fold diluted bovine serum albumin antibody solution. The special chip architecture and high image quality introduce an array screening method using SPRi detection.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE) 1934-2608/2018/$25.00 © 2018 SPIE
Yi Sun, Haoyuan Cai, and Xiaoping Wang "Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation," Journal of Nanophotonics 13(1), 012507 (16 November 2018). https://doi.org/10.1117/1.JNP.13.012507
Received: 18 June 2018; Accepted: 24 October 2018; Published: 16 November 2018
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Cited by 3 scholarly publications and 1 patent.
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KEYWORDS
Gold

Surface plasmons

Sensors

Polarization

Plasmonics

Modulation

Particle swarm optimization

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