Mr. John Moore Profile

John Moore

at Western University

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Proceedings Article | 29 March 2024 Presentation + Paper

Physical replication and validation of mathematical mitral valve models

Patrick Carnahan, Charles C. Yuan, John Moore, Gianluigi Bisleri, Daniel Bainbridge, Terry Peters, Elvis C. Chen

Proceedings Volume 12928, 1292807 (2024) https://doi.org/10.1117/12.3006494

KEYWORDS: Mathematical modeling, Education and training, 3D modeling, Heart, Modeling, Doppler effect, Computer simulations, Silicon

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Accurate models of the mitral valve are highly valuable for studying the physiology of the heart and its various pathologies, as well as creating physical replicas for cardiac surgery training. Currently, heart simulator technologies are used which rely on patient-specific data to create valve replicas. Alternatively, mathematical models of the mitral valve have been developed for computational applications. However, there are no studies that mathematically model both the mitral valve’s leaflets and its saddle-shaped annulus in a single design together in current literature. This results in anatomic inaccuracies in current models, as either only the leaflets or the saddle-shaped annulus are realistically modelled. Mathematical models to date have not been replicated as dynamic, physical valves and validated in a heart simulator system. We propose a new parametric representation of the mitral valve based on a combination of valve models from prior literature, combining both accurate leaflet shape, and annular geometry. A physical silicone replica of the model is created and validated in a pulse duplicator. Using a transesophageal echocardiography probe with color Doppler imaging, we demonstrate that our combined model replicates healthy valve behaviour, showing no regurgitation at realistic pressure gradients across the valve.

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