Dr. Matthew A. Jolley Profile

Dr. Matthew A. Jolley

at Children's Hospital of Philadelphia

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Author

Publications (5)

SPIE Journal Paper | 14 May 2024

Open-source graphical user interface for the creation of synthetic skeletons for medical image analysis

Christian Herz, Nicolas Vergnet, Sijie Tian, Abdullah Aly, Matthew Jolley, Nathanael Tran, Gabriel Arenas, Andras Lasso, Nadav Schwartz, Kathleen O’Neill, Paul Yushkevich, Alison Pouch

JMI, Vol. 11, Issue 03, 036001, (May 2024) https://doi.org/10.1117/12.10.1117/1.JMI.11.3.036001

KEYWORDS: Deformation, Anatomy, Modeling, Image segmentation, 3D modeling, Human-machine interfaces, Design, Medical imaging, Biomedical applications, Shape analysis

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PurposeDeformable medial modeling is an inverse skeletonization approach to representing anatomy in medical images, which can be used for statistical shape analysis and assessment of patient-specific anatomical features such as locally varying thickness. It involves deforming a pre-defined synthetic skeleton, or template, to anatomical structures of the same class. The lack of software for creating such skeletons has been a limitation to more widespread use of deformable medial modeling. Therefore, the objective of this work is to present an open-source user interface (UI) for the creation of synthetic skeletons for a range of medial modeling applications in medical imaging.ApproachA UI for interactive design of synthetic skeletons was implemented in 3D Slicer, an open-source medical image analysis application. The steps in synthetic skeleton design include importation and skeletonization of a 3D segmentation, followed by interactive 3D point placement and triangulation of the medial surface such that the desired branching configuration of the anatomical structure’s medial axis is achieved. Synthetic skeleton design was evaluated in five clinical applications. Compatibility of the synthetic skeletons with open-source software for deformable medial modeling was tested, and representational accuracy of the deformed medial models was evaluated.ResultsThree users designed synthetic skeletons of anatomies with various topologies: the placenta, aortic root wall, mitral valve, cardiac ventricles, and the uterus. The skeletons were compatible with skeleton-first and boundary-first software for deformable medial modeling. The fitted medial models achieved good representational accuracy with respect to the 3D segmentations from which the synthetic skeletons were generated.ConclusionsSynthetic skeleton design has been a practical challenge in leveraging deformable medial modeling for new clinical applications. This work demonstrates an open-source UI for user-friendly design of synthetic skeletons for anatomies with a wide range of topologies.

Proceedings Article | 29 March 2024 Presentation + Paper

3D echocardiogram visualization: a new method based on focus + context

Samuelle St-Onge, Silvani Amin, Alana Cianciulli, Matthew Jolley, Simon Drouin

Proceedings Volume 12929, 129290T (2024) https://doi.org/10.1117/12.3006214

KEYWORDS: Visualization, Anatomy, Volume rendering, Opacity, Voxels, Heart, Optical transfer functions, Echocardiography, Ultrasonography, Magnetic resonance imaging

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Proceedings Article | 3 April 2023 Poster + Paper

Skeletal modeling of the tricuspid valve via cylindrical parameterization

Jared Vicory, Christian Herz, Maura Flynn, Alana Cianciulli, Patricia Sabin, Andras Lasso, Matthew Jolley, Beatriz Paniagua

Proceedings Volume 12464, 1246431 (2023) https://doi.org/10.1117/12.2654364

KEYWORDS: Image segmentation, Anatomy, Modeling, Heart, Statistical analysis

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Proceedings Article | 16 March 2020 Paper

Patient-specific, dynamic models of hypoplastic left heart syndrome tricuspid valves for simulation and planning

Nora Boone, Hannah Nam, John Moore, Patrick Carnahan, Olivia Ginty, Christian Herz, Andras Lasso, Matthew Jolley, Elvis C. Chen, Terry Peters

Proceedings Volume 11315, 113152E (2020) https://doi.org/10.1117/12.2549745

KEYWORDS: Process modeling, 3D modeling, Heart, Silicon, Pathology, Image segmentation, Data modeling, Ultrasonography, Surgery, Visual process modeling

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Proceedings Article | 3 March 2017 Presentation + Paper

Patient-specific pediatric silicone heart valve models based on 3D ultrasound

Anna Ilina, Andras Lasso, Matthew Jolley, Brittany Wohler, Alex Nguyen, Adam Scanlan, Zachary Baum, Frank McGowan, Gabor Fichtinger

Proceedings Volume 10135, 1013516 (2017) https://doi.org/10.1117/12.2255849

KEYWORDS: Cardiac imaging, Echocardiography, Education and training, Modeling and simulation, Heart, 3D modeling, Surgery, Silicon, Image segmentation, Ultrasonography, 3D printing, Software development, Cancer, Skin, Visual process modeling

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