Investigating fluorescence lifetime signatures for normal tissue adjacent to cancer in oropharyngeal squamous cell carcinomas

Katjana Ehrlich; Kelsey T. Hadfield; Lisanne Kraft; Mohamed A. Hassan; Brent W. Weyers; Xiangnan Zhou; Julien Bec; Dorina Gui; Arnaud F. Bewley; Marianne Abouyared; D. Gregory Farwell; Andrew C. Birkeland; Laura Marcu

doi:10.1117/12.3003488

13 March 2024 Investigating fluorescence lifetime signatures for normal tissue adjacent to cancer in oropharyngeal squamous cell carcinomas

Katjana Ehrlich, Kelsey T. Hadfield, Lisanne Kraft, Mohamed A. Hassan, Brent W. Weyers, Xiangnan Zhou, Julien Bec, Dorina Gui, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew C. Birkeland, Laura Marcu

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Proceedings Volume PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024; (2024) https://doi.org/10.1117/12.3003488
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present a study investigating fluorescence lifetime signatures of normal tissues adjacent to tumors (NATs) in head and neck squamous cell carcinoma (HNSCC) using fluorescence lifetime imaging (FLIm). Label-free FLIm offers insight into the metabolic activity and extracellular matrix composition. Understanding the metabolic activity, tissue heterogeneity and tumor-associated alterations in these transition areas can enhance the accuracy of margin delineation. Initial results show that the fluorescence lifetime is gradually increasing from shorter to longer lifetimes with increasing distance from the cancer and with varying magnitudes of change being observed in the individual emission bands.

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Katjana Ehrlich, Kelsey T. Hadfield, Lisanne Kraft, Mohamed A. Hassan, Brent W. Weyers, Xiangnan Zhou, Julien Bec, Dorina Gui, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew C. Birkeland, and Laura Marcu "Investigating fluorescence lifetime signatures for normal tissue adjacent to cancer in oropharyngeal squamous cell carcinomas", Proc. SPIE PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024, (13 March 2024); https://doi.org/10.1117/12.3003488

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KEYWORDS

Tissues

Cancer

Fluorescence

Head

Neck

Tumors

Collagen

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