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A robust multi-volume three-dimensional (3D) registration algorithm is introduced to improve the contrast of optical coherence tomography (OCT) volumes. Our method involves registering multiple volumes to a selected reference volume to correct for the translational and rotational differences between each target and the reference volume and averaging the registered volumes. We tested our registration algorithm on the volumes obtained from three OCT systems with different field-of-views and resolutions. To demonstrate its accuracy, our developed method is evaluated using two different metrics, and its advantages over the other registration algorithms and its limitations are discussed.
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