Portable and eye-safe Raman spectroscopy for point-of-care neurological diagnostics

Georgia Harris; Carl Banbury; Michael Clancy; Neil Eisenstein; Iain Styles; Ann Logan; Antonio Belli; Pola Goldberg Oppenheimer

doi:10.1117/12.2608249

7 March 2022 Portable and eye-safe Raman spectroscopy for point-of-care neurological diagnostics

Georgia Harris, Carl Banbury, Michael Clancy, Neil Eisenstein, Iain Styles, Ann Logan, Antonio Belli, Pola Goldberg Oppenheimer

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Proceedings Volume PC11968, Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics; PC1196805 (2022) https://doi.org/10.1117/12.2608249
Event: SPIE BiOS, 2022, San Francisco, California, United States

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Abstract

Raman Spectroscopy (RS) and machine learning are explored for the rapid, real-time, sensitive application of neurological diagnostics through the human eye. Biochemical information is obtained of fatty porcine tissue and flat-mounted porcine retinal samples using an in-house built, portable RS system. RS and FUNDUS imaging have been combined with a phantom eye model to obtain spectra under eye-safe parameters in an in-vivo environment, identifying high wavenumber bands. This system has the potential to detect acute, biochemical changes indicative of neurodegenerative disorders such as Traumatic Brain Injury for early and accurate diagnoses, crucial for neurological recovery.

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Georgia Harris, Carl Banbury, Michael Clancy, Neil Eisenstein, Iain Styles, Ann Logan, Antonio Belli, and Pola Goldberg Oppenheimer "Portable and eye-safe Raman spectroscopy for point-of-care neurological diagnostics", Proc. SPIE PC11968, Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics, PC1196805 (7 March 2022); https://doi.org/10.1117/12.2608249

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KEYWORDS

Diagnostics

Remote sensing

Point-of-care devices

Raman spectroscopy

Photography

Eye

Tissues

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