Phase-restoring subpixel image registration and automated signal extraction for optoretinography using phase-sensitive OCTs

Tong Ling; Huakun Li; Bingyao Tan; Vimal P. Pandiyan; Veluchamy A. Barathi; Ramkumar Sabesan; Leopold Schmetterer

doi:10.1117/12.2649502

24 April 2023 Phase-restoring subpixel image registration and automated signal extraction for optoretinography using phase-sensitive OCTs

Tong Ling, Huakun Li, Bingyao Tan, Vimal P. Pandiyan, Veluchamy A. Barathi, Ramkumar Sabesan, Leopold Schmetterer

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Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC123600D (2023) https://doi.org/10.1117/12.2649502
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Phase-sensitive OCT can be used for imaging the photoreceptor deformations in response to the light stimulus or optoretinography (ORG). Here, we propose a phase-restoring subpixel image registration method and an automated signal extraction algorithm for optoretinography using phase-sensitive OCTs. We validated these methods in simulations, phantom experiments, and in-vivo optoretinogram imaging. Our image registration method yields better amplitude stability and higher phase accuracy compared with conventional approaches, and we found two types of signals (one monophasic and the other biphasic) simultaneously in rodent ORG imaging. These results can be beneficial to the ongoing preclinical/clinical ORG studies.

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Tong Ling, Huakun Li, Bingyao Tan, Vimal P. Pandiyan, Veluchamy A. Barathi, Ramkumar Sabesan, and Leopold Schmetterer "Phase-restoring subpixel image registration and automated signal extraction for optoretinography using phase-sensitive OCTs", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600D (24 April 2023); https://doi.org/10.1117/12.2649502

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KEYWORDS

Image registration

Optical coherence tomography

Image segmentation

Image processing algorithms and systems

In vivo imaging

Motion models

Signal detection

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