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Colorectal cancer (CRC) is the third most common and the second most deadly type of cancer worldwide. Currently, early-stage CRC detection is hindered by the limited information gold standard screening and diagnostic procedures (colonoscopies) provide on tissue structural changes. Accuracy of early CRC detection during colonoscopy and CRC delineation during microsurgery can potentially be increased by adding tissue molecular information in real-time. We developed a molecular-sensitive tool capable of determining depth-resolved fluorophore and chromophore concentrations, as well as scattering properties from wavelength-resolved fluorescence spectra alone. Normal mucosa and CRC exhibited differences in elastin, flavin, bile and lipid concentrations.
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Marcelo Saito Nogueira, Robert Matthews, Shane Killeen, Micheal O'Riordain, Stefan Andersson-Engels, "Fluorescence spectroscopy based estimation of biochemical concentrations and scattering properties for colorectal cancer detection," Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC1236108 (17 March 2023); https://doi.org/10.1117/12.2650441