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15 March 2023 New chemical microscopies to inform the design of pharmaceutical formulations (Conference Presentation)
Garth J. Simpson
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Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920B (2023) https://doi.org/10.1117/12.2653264
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
A suite of novel chemical imaging methods has been developed to collectively inform on the design and optimization of storage and delivery platforms for therapeutic molecules. Brought into dramatic relief by cold-storage constraints in COVID-19 vaccines, the shelf-lives and storage conditions of pharmaceutical materials can profoundly impact global access to life-saving medications. Our group has developed a suite of complementary chemical imaging methods that collectively provide unique insights into critical factors affecting stability and bioavailability of amorphous solid dispersions (ASDs), used routinely for pharmaceutical formulations. Methods and applications of these novel approaches will be summarized.
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Garth J. Simpson "New chemical microscopies to inform the design of pharmaceutical formulations (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920B (15 March 2023); https://doi.org/10.1117/12.2653264
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KEYWORDS
Microscopy
Imaging spectroscopy
Crystals
Harmonic generation
Luminescence
Mid-IR
Molecules
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