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13 March 2024 Enhancing efficacy in hypoxic HNC spheroids with PDT-based combinatorial treatments
Marvin Xavierselvan, Vicky Yang, Srivalleesha Mallidi
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC128230B (2024) https://doi.org/10.1117/12.3003300
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Head and neck cancer (HNC) presents challenges due to its heterogeneity, high recurrence rate, and hypoxic microenvironments. Current treatments fall short, leading to high morbidity and mortality. Photodynamic therapy (PDT) offers spatiotemporal tumor control but relies on oxygenation, posing limitations in hypoxic tumors. Combining hypoxia-activated prodrugs with PDT can selectively kill hypoxic tumor cells and reduce the tumor burden. This study proposes using evofosfamide, a hypoxia-activated prodrug, in combination with benzoporphyrin derivative (BPD)-PDT in a 3D spheroids model of HNC. The growth profile, BPD uptake profile, and hypoxia development were investigated. Combination therapy enhanced PDT efficacy in hypoxic HNC spheroids.
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Marvin Xavierselvan, Vicky Yang, and Srivalleesha Mallidi "Enhancing efficacy in hypoxic HNC spheroids with PDT-based combinatorial treatments", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC128230B (13 March 2024); https://doi.org/10.1117/12.3003300
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KEYWORDS
Photodynamic therapy
Tumors
3D modeling
Hypoxia
Cancer
Control systems
Head
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