PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Stereotactic needle biopsy is a time-consuming and invasive procedure that often cannot accurately distinguish recurrent tumors from treatment effect in gliomas. We report an intraoperative multispectral fluorescence lifetime imaging (FLIm) system coupled with a custom-made fiber optic probe integrated with the stealth biopsy needle as an optical biopsy tool. FLIm parameters collected from 3 suspected recurrent glioma patients changed over the biopsy trajectory as the needle passed different brain areas. An SVM classifier validated using a leave-one-patient-out validation scheme could identify the lesions from the normal surrounding tissue with sensitivity=0.99, specificity=0.91, and accuracy=0.95.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Silvia N. Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu, "Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)," Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC1283101 (13 March 2024); https://doi.org/10.1117/12.3001898