PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Triple-negative breast cancer (TNBC) is a challenging disease to treat and there is an unmet need to introduce new tools that offers comprehensive molecular imaging of tissues. Here we introduce an untargeted correlative molecular imaging approach to shed light on TNBC responders and non-responders to chemotherapy. Desorption electrospray ionization (DESI) -mass spectrometry (MS) is an ambient technique for lipidomic/metabolomic imaging. We have developed a comprehensive pipeline to correlate Raman spectroscopy and Fourier-transform infrared spectroscopy imaging with DESI-MSI. This highly complementary transformative imaging tool can enable disruptive research by providing insights in monitoring TNBC progression and identification of new therapeutic targets.
Shiyue Liu,Maddy Parsons,Vincenzo Abbate,Ka Lung Andrew Chan, andMads S. Bergholt
"Correlated vibrational spectroscopies and mass spectrometry imaging of tissues", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC128340F (13 March 2024); https://doi.org/10.1117/12.3001794
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Shiyue Liu, Maddy Parsons, Vincenzo Abbate, Ka Lung Andrew Chan, Mads S. Bergholt, "Correlated vibrational spectroscopies and mass spectrometry imaging of tissues," Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC128340F (13 March 2024); https://doi.org/10.1117/12.3001794