We present a novel optical sensor platform designed for the detection of medical biomarkers. The sensor operates by utilizing reflection variation resulting from the modification of Fano resonance conditions. By fabricating one- and two-dimensional subwavelength quasi-periodic structures made of polymer and coated with an inorganic layer, we enable the functionality of the sensor, ultimately leading to increased sensitivity and detection threshold. The development of the sensor’s platform involves a multi-step process. The detection mechanism primarily relies on the optical response of the biosensor. The presence of analytes induces a spectral shift of the Fano resonance, which is caused by the modification of the biolayer thickness. This optical sensor platform holds significant potential for the detection of a variety of medical biomarkers, including analytes related to various pathogenes, cancer biomarkers, and others.
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