Television Microdensitometry In The Life Sciences

Ronald A . Swenson; Colin P. Bond

doi:10.1117/12.953802

1 March 1974 Television Microdensitometry In The Life Sciences

Ronald A . Swenson, Colin P. Bond

Proceedings Volume 0040, Quantitative Imagery in the Biomedical Sciences II; (1974) https://doi.org/10.1117/12.953802
Event: Annual Technical Symposium, 1973, San Diego, United States

Abstract

Densitometry is a measurement of the absorption of light 1:), a material to give its optical density. Data can be used to plot the change in optical density across a region of a microscope specimen. In most practical applications microdensitometry provides an absolute or relative determination of some chemical component of the specimen by measurement of its total integrated density contribution. Integrated density determinations of this type have an increasingly wide range of applications in many biological fields and such measurements on DNA have been used in the study of various types of cancer. Microdensitometry can be used to study the biochemistry of individual cells and their alteration in disease states. Conventional microdensitometry is perfor ed by means of mechanical object plane scanning systems which are often modified microspectrophotometers. The systems are inherently accurate but are generally too slow to allow the accumulation of data from large populations frequently required for reasonable statistical accuracy. MAINCO has developed a faster television type microdensitometer system which offers great promise in biomedical research.

Citation Download Citation

Ronald A . Swenson and Colin P. Bond "Television Microdensitometry In The Life Sciences", Proc. SPIE 0040, Quantitative Imagery in the Biomedical Sciences II, (1 March 1974); https://doi.org/10.1117/12.953802

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