FDTD based model of ISOCT imaging for validation of nanoscale sensitivity (Conference Presentation)

Aya Eid; Di Zhang; Ji Yi; Vadim Backman

doi:10.1117/12.2253058

24 April 2017 FDTD based model of ISOCT imaging for validation of nanoscale sensitivity (Conference Presentation)

Aya Eid, Di Zhang, Ji Yi, Vadim Backman

Proceedings Volume 10075, Biophysics, Biology and Biophotonics II: the Crossroads; 100750F (2017) https://doi.org/10.1117/12.2253058
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Many of the earliest structural changes associated with neoplasia occur on the micro and nanometer scale, and thus appear histologically normal. Our group has established Inverse Spectroscopic OCT (ISOCT), a spectral based technique to extract nanoscale sensitive metrics derived from the OCT signal. Thus, there is a need to model light transport through relatively large volumes (< 50 um^3) of media with nanoscale level resolution. Finite Difference Time Domain (FDTD) is an iterative approach which directly solves Maxwell’s equations to robustly estimate the electric and magnetic fields propagating through a sample. The sample’s refractive index for every spatial voxel and wavelength are specified upon a grid with voxel sizes on the order of λ/20, making it an ideal modelling technique for nanoscale structure analysis. Here, we utilize the FDTD technique to validate the nanoscale sensing ability of ISOCT. The use of FDTD for OCT modelling requires three components: calculating the source beam as it propagates through the optical system, computing the sample’s scattered field using FDTD, and finally propagating the scattered field back through the optical system. The principles of Fourier optics are employed to focus this interference field through a 4f optical system and onto the detector. Three-dimensional numerical samples are generated from a given refractive index correlation function with known parameters, and subsequent OCT images and mass density correlation function metrics are computed. We show that while the resolvability of the OCT image remains diffraction limited, spectral analysis allows nanoscale sensitive metrics to be extracted.

Conference Presentation

Citation Download Citation

Aya Eid, Di Zhang, Ji Yi, and Vadim Backman "FDTD based model of ISOCT imaging for validation of nanoscale sensitivity (Conference Presentation)", Proc. SPIE 10075, Biophysics, Biology and Biophotonics II: the Crossroads, 100750F (24 April 2017); https://doi.org/10.1117/12.2253058

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Finite-difference time-domain method

Optical coherence tomography

Beam propagation method

Correlation function

Modeling

Refractive index

Statistical analysis

Show All Keywords

Keywords/Phrases

Search In:

Publication Years