The physical basis of biomedical optical imaging using time-dependent measurements of photon migration in the frequency-domain

E. M. Sevick

doi:10.1117/12.2283774

5 August 1993 The physical basis of biomedical optical imaging using time-dependent measurements of photon migration in the frequency-domain

E. M. Sevick

Author Affiliations +

Proceedings Volume 10311, Medical Optical Tomography: Functional Imaging and Monitoring; 103110T (1993) https://doi.org/10.1117/12.2283774
Event: Medical Optical Tomography: Functional Imaging and Monitoring, 1993, Bellingham, WA, United States

Abstract

A physical model of how optical heterogeneities affect time-dependent measurements of photon migration in tissue-like scattering media is presented. Using this model, changes in frequency-domain measurements of phase-shift, 0, and amplitude modulation, M, are predicted in the presence of transparent and perfectly absorbing objects. Two-dimensional Monte Carlo simulations of photon migration and single-pixel measurements of 0 and M confirm the physical model. Recent experimental "images" from multi-pixel measurements of 0 and M are also consistent with the physical model. These results suggest that two dimensional frequency-domain measurements provide direct information for detection and three dimensional localization of optical heterogeneities without the use of computer intensive reconstruction algorithms.

Citation Download Citation

E. M. Sevick "The physical basis of biomedical optical imaging using time-dependent measurements of photon migration in the frequency-domain", Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 103110T (5 August 1993); https://doi.org/10.1117/12.2283774

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