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The oxygenation of human forearm muscle tissue can be investigated using near infrared spectroscopy (NIRS). Oxy and deoxy hemoglobin changes can be quantified combining attenuation measurements with pathlength data obtained by time resolved spectroscopy. This study reports some applications of NIRS to non- invasive measurements of skeletal muscle oxygenation in untrained volunteers and patients.
Marco Ferrari
"Quantitative measurement of skeletal muscle oxygenation by combined near infrared time resolved and unresolved spectroscopy", Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 103110Z (5 August 1993); https://doi.org/10.1117/12.2283780
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Marco Ferrari, "Quantitative measurement of skeletal muscle oxygenation by combined near infrared time resolved and unresolved spectroscopy," Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 103110Z (5 August 1993); https://doi.org/10.1117/12.2283780