A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system

Srinivasan Vedantham; Suman Shrestha; Andrew Karellas; Sang Hyun Cho

doi:10.1117/12.2279351

7 September 2017 A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system

Srinivasan Vedantham, Suman Shrestha, Andrew Karellas, Sang Hyun Cho

Proceedings Volume 10393, Radiation Detectors in Medicine, Industry, and National Security XVIII; 103930R (2017) https://doi.org/10.1117/12.2279351
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

Dual-modality Computed Tomography (CT)/X-ray Fluorescence Computed Tomography (XFCT) can be a valuable tool for imaging and quantifying the organ and tissue distribution of small concentrations of high atomic number materials in small-animal system. In this work, the framework for optimizing the micro-CT imaging system component of the dual-modality system is described, either when the micro-CT images are concurrently acquired with XFCT and using the x-ray spectral conditions for XFCT, or when the micro-CT images are acquired sequentially and independently of XFCT. This framework utilizes the cascaded systems analysis for task-specific determination of the detectability index using numerical observer models at a given radiation dose, where the radiation dose is determined using Monte Carlo simulations.

Citation Download Citation

Srinivasan Vedantham, Suman Shrestha, Andrew Karellas, and Sang Hyun Cho "A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system", Proc. SPIE 10393, Radiation Detectors in Medicine, Industry, and National Security XVIII, 103930R (7 September 2017); https://doi.org/10.1117/12.2279351

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